Below are some details about the DYRK1A Scientific Conference, for further details visit http://www.dyrk-conference.com/
Abnormalities in DYRK1A dosage are associated with cognitive disorders observed in Down syndrome, Mental Retardation Disease 7 (MRD7) and Alzheimer’s disease. DYRK1A plays key functions in pancreatic cells, cancer, inflammation, megakaryoblastic leukemia. Close orthologs are found in plants, yeast, algae and unicellular parasites.
he conference will focus on DYRK1A, DYRK1B, 2, 3, 4 and the closely related CLKs (‘cdc2-like kinases’). Presentations will cover all structural (crystal structures), regulatory and functional aspects of these kinases, their substrate specificity, functions at the cell and organism levels, the development of potent and selective pharmacological inhibitors and their potential therapeutic use as treatment of various human disease.